Thereafter, patients took two treatment doses one morning and one afternoon dose until the end of the treatment period. January Dopidines, a new class of pharmaceutical compounds, act as dopaminergic stabilizers, enhancing or counteracting dopaminergic effects in the central nervous system. However, further data analysis indicates that pridopidine may still hold promise.
Thereafter, patients took two doses one morning and one afternoon dose until the end of the treatment period. Pridopidine therefore plays two opposing roles in the brain, which stabilize dopamine levels. In this way, pridopidine is thought to help the brain reestablish a normal balance of neurotransmitters, and thus regain control over motion. Pridopidine for the treatment of Huntington's disease. Specifically, pridopidine is believed to work by stabilizing levels of the neurotransmitter dopamine in the brain.
It results from an expanded unstable trinucleotide repeat in the coding region of the huntingtin gene. Furthermore, it is very well tolerated, even when patients are taking other drugs, such as antipsychotics. The study was also conducted to see whether pridopidine is effective and safe, and to establish an optimal dose. In this way, pridopidine blocks the dopamine receptor from sensing and responding to dopamine when dopamine levels are too high Pontel et al.
However, the magnitude of the improvements was small. This highly technical article discusses how Pridopidine is believed to work in the brain.
Huntington's Patients May See Delay in Fuctional Decline with Pridopidine
Neurosearch has declared that it will carry out a further trial, but has not yet announced further details. Non-choreic derangements in voluntary movement contribute to overall motor disability and are poorly addressed by current therapies. Expert Opin Investig Drugs. Huntington's disease is a rare dominantly-inherited neurodegenerative disease with motor, cognitive and behavioral manifestations. Pridopidine was also very well tolerated, had an adverse event profile similar to placebo and gave no indication of treatment-associated worsening of symptoms.
Conversely, when levels of dopamine are low, pridopidine has a round-about way of increasing dopamine production. The brain walks a tightrope as it tries to maintain the right balance of neurotransmitters, and the slightest disturbance can cause movements to falter Andre et al. This causes miscommunication between different parts of the brain. The purpose of the open-label segment of the study was to test whether pridopidine is safe and effective for longer periods of time.
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